Responsiveness and minimal clinically important differences after cholecystectomy: GIQLI versus SF-36

J Gastrointest Surg. 2008 Jul;12(7):1275-82. doi: 10.1007/s11605-008-0526-7. Epub 2008 May 3.


Introduction: To compare responsiveness and minimal clinically important differences (MCID) between the Gastrointestinal Quality of Life (GIQLI) and the Short Form 36 (SF-36), we prospectively analyze 159 patients undergoing cholecystectomy at two tertiary academic hospitals.

Patients and methods: All patients completed the disease-specific GIQLI and the generic SF-36 before and 3 months after surgery. Scores using these instruments were interpreted by generalized estimating equation before and after cholecystectomy. The bootstrap estimation was used to derive 95% confidence intervals for differences in the responsiveness estimates.

Results and discussion: Mean changes in all GIQLI and the SF-36 subscales were statistically significant (p < 0.05). Comparisons of effect size (ES), standardized response means (SRM), and relative efficiency (>1) indicated that the responsiveness of the GIQLI was superior to that of the SF-36. In the equivalence test, all lower or upper confidence limits presented no equivalence (>5), indicating good MCID. The ES and SRM for emotions and physical function in the GIQLI significantly differed from those of the SF-36 (p < 0.05).

Conclusion: The data in this study indicate that clinicians and health researchers should weight disease-specific measures more heavily than generic measures when evaluating treatment outcomes.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cholecystectomy / methods*
  • Female
  • Follow-Up Studies
  • Health Status Indicators*
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Postoperative Period
  • Quality of Life*
  • Surveys and Questionnaires*
  • Taiwan
  • Treatment Outcome