[Osteoporosis and fractures associated with drugs]

Ugeskr Laeger. 2008 Apr 28;170(18):1550-5.
[Article in Danish]


Drugs can affect the skeleton in different ways. Antiepileptic drugs were not associated with any major fracture risk. Lithium was associated with a decreased fracture risk. Insulin, sulphonylureas and metformin were associated with a decreased risk, whereas glitazones were associated with an increased risk. Blood pressure lowering drugs, thiazide diuretics and nitroglycerin were associated with a decreased risk of fractures, whereas amiodarone and loop diuretics were associated with an increased risk. Pain medication varied from no effect to an increased fracture risk.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Analgesics / adverse effects
  • Antineoplastic Agents / adverse effects
  • Bone Density / drug effects
  • Cardiovascular Agents / adverse effects
  • Central Nervous System Agents / adverse effects
  • Drug-Related Side Effects and Adverse Reactions*
  • Fractures, Spontaneous / chemically induced*
  • Humans
  • Hypoglycemic Agents / adverse effects
  • Osteoporosis / chemically induced*
  • Risk Factors


  • Analgesics
  • Antineoplastic Agents
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Hypoglycemic Agents