The economic burden of noncervical human papillomavirus disease in the United States

Am J Obstet Gynecol. 2008 May;198(5):500.e1-7. doi: 10.1016/j.ajog.2008.03.064.

Abstract

Objective: The purpose of this study was (1) to estimate the direct medical costs of 7 major noncervical human papillomavirus (HPV)-related conditions that include genital cancers, mouth and oropharyngeal cancers, anogenital warts, and juvenile-onset recurrent respiratory papillomatosis, and (2) to approximate the economic burden of noncervical HPV disease.

Study design: For each condition, we synthesized the best available secondary data to produce lifetime cost per case estimates, which were expressed in present value. Using an incidence-based approach, we then applied these costs to develop an aggregate measure of economic burden.

Results: The economic burden that was associated with noncervical HPV-6-, -11-, -16-, and -18-related conditions in the US population in the year 2003 approximates $418 million (range, $160 million to $1.6 billion).

Conclusion: The economic burden of noncervical HPV disease is substantial. Analyses that assess the value of investments in HPV prevention and control programs should take into account the costs and morbidity and mortality rates that are associated with these conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Anus Neoplasms / economics
  • Anus Neoplasms / epidemiology
  • Anus Neoplasms / virology
  • Cost of Illness*
  • Costs and Cost Analysis
  • Female
  • Human papillomavirus 11
  • Human papillomavirus 16
  • Human papillomavirus 18
  • Human papillomavirus 6
  • Humans
  • Male
  • Mouth Neoplasms / economics
  • Mouth Neoplasms / virology
  • Neoplasms / economics*
  • Neoplasms / epidemiology
  • Neoplasms / virology*
  • Oropharyngeal Neoplasms / economics
  • Oropharyngeal Neoplasms / epidemiology
  • Oropharyngeal Neoplasms / virology
  • Papilloma / economics
  • Papilloma / virology
  • Papillomavirus Infections / economics*
  • Papillomavirus Infections / prevention & control
  • Penile Neoplasms / economics
  • Penile Neoplasms / epidemiology
  • Penile Neoplasms / virology
  • Pharyngeal Neoplasms / economics
  • Pharyngeal Neoplasms / virology
  • Respiratory Tract Neoplasms / economics
  • Respiratory Tract Neoplasms / virology
  • United States / epidemiology
  • Vaginal Neoplasms / economics
  • Vaginal Neoplasms / epidemiology
  • Vaginal Neoplasms / virology
  • Vulvar Neoplasms / economics
  • Vulvar Neoplasms / epidemiology
  • Vulvar Neoplasms / virology
  • Warts / economics