CaMKII: new tricks for an old dog

Cell. 2008 May 2;133(3):397-9. doi: 10.1016/j.cell.2008.04.018.


Calcium/calmodulin-dependent protein kinase II (CaMKII) is a pivotal signaling molecule in both the brain and the heart. In this issue of Cell, Erickson et al. (2008) demonstrate a mechanism for CaMKII activation by reactive oxygen species that provides a direct link between kinase activation and cardiac dysfunction.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
  • Enzyme Activation
  • Heart Diseases / metabolism*
  • Humans
  • Myocytes, Cardiac / metabolism*
  • Reactive Oxygen Species / metabolism


  • Reactive Oxygen Species
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2