Association between alcohol consumption and both osteoporotic fracture and bone density
- PMID: 18456037
- PMCID: PMC2692368
- DOI: 10.1016/j.amjmed.2007.12.012
Association between alcohol consumption and both osteoporotic fracture and bone density
Abstract
Objective: Alcoholism is a risk factor for osteoporotic fractures and low bone density, but the effects of moderate alcohol consumption on bone are unknown. We performed a systematic review and meta-analysis to assess the associations between alcohol consumption and osteoporotic fractures, bone density and bone density loss over time, bone response to estrogen replacement, and bone remodeling.
Methods: MEDLINE, Current Contents, PsychINFO, and Cochrane Libraries were searched for studies published before May 14, 2007. We assessed quality using the internal validity criteria of the US Preventive Services Task Force.
Results: We pooled effect sizes for 2 specific outcomes (hip fracture and bone density) and synthesized data qualitatively for 4 outcomes (non-hip fracture, bone density loss over time, bone response to estrogen replacement, and bone remodeling). Compared with abstainers, persons consuming from more than 0.5 to 1.0 drinks per day had lower hip fracture risk (relative risk=0.80 [95% confidence interval, 0.71-0.91]), and persons consuming more than 2 drinks per day had higher risk (relative risk=1.39 [95% confidence interval, 1.08-1.79]). A linear relationship existed between femoral neck bone density and alcohol consumption. Because studies often combined moderate and heavier drinkers in a single category, we could not assess relative associations between alcohol consumption and bone density in moderate compared with heavy drinkers.
Conclusion: Compared with abstainers and heavier drinkers, persons who consume 0.5 to 1.0 drink per day have a lower risk of hip fracture. Although available evidence suggests a favorable effect of alcohol consumption on bone density, a precise range of beneficial alcohol consumption cannot be determined.
Figures
Similar articles
-
Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures: A Dose-Response Meta-Analysis.Int J Environ Res Public Health. 2022 Jan 28;19(3):1515. doi: 10.3390/ijerph19031515. Int J Environ Res Public Health. 2022. PMID: 35162537 Free PMC article.
-
Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study.Osteoporos Int. 2007 May;18(5):593-602. doi: 10.1007/s00198-006-0287-7. Epub 2007 Feb 21. Osteoporos Int. 2007. PMID: 17318666
-
Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men.J Am Geriatr Soc. 2006 Nov;54(11):1649-57. doi: 10.1111/j.1532-5415.2006.00912.x. J Am Geriatr Soc. 2006. PMID: 17087690
-
Alcohol Consumption and All-Cause Mortality: A Systematic Review [Internet].Alexandria (VA): USDA Nutrition Evidence Systematic Review; 2020 Jul. Alexandria (VA): USDA Nutrition Evidence Systematic Review; 2020 Jul. PMID: 35353467 Free Books & Documents. Review.
-
The role of sarcopenia in the risk of osteoporotic hip fracture.Clin Rheumatol. 2015 Oct;34(10):1673-80. doi: 10.1007/s10067-015-2943-9. Epub 2015 Apr 26. Clin Rheumatol. 2015. PMID: 25912213 Review.
Cited by
-
Developing a calculable risk prediction model for sternal wound infection after median sternotomy: a retrospective study.Burns Trauma. 2024 Sep 13;12:tkae031. doi: 10.1093/burnst/tkae031. eCollection 2024. Burns Trauma. 2024. PMID: 39282020 Free PMC article.
-
Association between Bone Quality and Physical Activity in Community-Dwelling Older Adults.Geriatrics (Basel). 2024 May 11;9(3):62. doi: 10.3390/geriatrics9030062. Geriatrics (Basel). 2024. PMID: 38804319 Free PMC article.
-
Six months of voluntary alcohol consumption in male cynomolgus macaques reduces intracortical bone porosity without altering mineralization or mechanical properties.Bone. 2024 Aug;185:117111. doi: 10.1016/j.bone.2024.117111. Epub 2024 Apr 26. Bone. 2024. PMID: 38679220
-
Association between alcohol intake and bone mineral density: results from the NHANES 2005-2020 and two-sample Mendelian randomization.Arch Osteoporos. 2024 Mar 28;19(1):21. doi: 10.1007/s11657-024-01382-7. Arch Osteoporos. 2024. PMID: 38546895
-
Improving patients' experiences of diagnosis and treatment of vertebral fracture: co-production of knowledge sharing resources.BMC Musculoskelet Disord. 2024 Feb 21;25(1):165. doi: 10.1186/s12891-024-07281-9. BMC Musculoskelet Disord. 2024. PMID: 38383386 Free PMC article.
References
-
- Advocacy News and Updates . National Osteoporosis Foundation; Washington DC: [Accessed June 28, 2007]. Available at: http://www.nof.org/advocacy/prevalence/index.htm.
-
- Osteoporosis Disease Facts . National Osteoporosis Foundation; Washington DC: [Accessed June 28, 2007]. Available at: http://www.nof.org/osteoporosis/diseasefacts.htm.
-
- Spencer H, Rubio N, Rubio E, et al. Chronic alcoholism. Frequently overlooked cause of osteoporosis in men. Am J Med. 1986;80:393–397. - PubMed
-
- Bikle DD, Genant HK, Cann C, et al. Bone disease in alcohol abuse. Ann Intern Med. 1985;103:42–48. - PubMed
-
- Lalor BC, France MW, Powell D, et al. Bone and mineral metabolism and chronic alcohol abuse. Q J Med. 1986;59:497–511. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
