Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study

Am J Obstet Gynecol. 2008 Aug;199(2):113.e1-5. doi: 10.1016/j.ajog.2008.02.026. Epub 2008 May 23.


Objective: Hysterectomy with concomitant cervical intraepithelial neoplasia (CIN), is often considered a definitive treatment for CIN, but development of subsequent vaginal intraepithelial neoplasia (VAIN) is known to range from 0.9% to 6.8%.

Study design: In a retrospective analysis of 3030 women with CIN2+ without history of VAIN in the University Hospital Gasthuisberg, Leuven, Belgium, from January 1989 until December 2003, we identified 125 women who underwent a hysterectomy within 6 months after diagnosis of CIN2+ and reviewed their postoperative Papanicolaou smears.

Results: Thirty-one patients (24.8%) were lost to follow-up. Seven of the 94 women in the follow-up group (7.4%) developed VAIN2+, of which 2 were invasive vaginal cancers. Median interval between hysterectomy and diagnosis of VAIN2+ was 35 months (5-103 months). Women with recurrence were significantly older (P = .003).

Conclusion: Hysterectomy may not be considered as a definitive therapy for CIN2+ because the incidence rate of subsequent VAIN2+ is as high as 7.4%.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Carcinoma in Situ / epidemiology*
  • Female
  • Humans
  • Hysterectomy* / methods
  • Middle Aged
  • Neoplasms, Multiple Primary / epidemiology*
  • Retrospective Studies
  • Uterine Cervical Dysplasia / surgery*
  • Uterine Cervical Neoplasms / surgery*
  • Vaginal Neoplasms / epidemiology*