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Comparative Study
. 2008 Aug;199(2):127.e1-6.
doi: 10.1016/j.ajog.2008.03.012. Epub 2008 May 5.

A national study of the complications of lupus in pregnancy

Megan E B Clowse  1 , Margaret Jamison, Evan Myers, Andra H James
Affiliations
Comparative Study

A national study of the complications of lupus in pregnancy

Megan E B Clowse et al. Am J Obstet Gynecol. 2008 Aug.

Abstract

Objective: This study was undertaken to determine the risk of rare complications during pregnancy for women with systemic lupus erythematosus.

Study design: By using the Nationwide Inpatient Sample from 2000-2003, we compared maternal and pregnancy complications for all pregnancy-related admissions for women with and without systemic lupus erythematosus.

Results: Of more than 16.7 million admissions for childbirth over the 4 years, 13,555 were to women with systemic lupus erythematosus. Maternal mortality was 20-fold higher among women with systemic lupus erythematosus. The risks for thrombosis, infection, thrombocytopenia, and transfusion were each 3- to 7-fold higher for women with systemic lupus erythematosus. Lupus patients also had a higher risk for cesarean sections (odds ratio: 1.7), preterm labor (odds ratio: 2.4), and preeclampsia (odds ratio: 3.0) than other women. Women with systemic lupus erythematosus were more likely to have other medical conditions, including diabetes, hypertension, and thrombophilia, that are associated with adverse pregnancy outcomes.

Conclusion: Women with systemic lupus erythematosus are at increased risk for serious medical and pregnancy complications during pregnancy.

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References

    1. Clark CA, Spitzer KA, Laskin CA. Decrease in pregnancy loss rates in patients with systemic lupus erythematosus over a 40-year period. J Rheumatol. 2005;32(9):1709–1712. - PubMed
    1. (HCUP) HCaUP. Overview of the Nationwide Inpatient Sample (NIS) 2000. Rockville, MD: The Agency for Healthcare Research and Quality; 2002.
    1. (HCUP) HCaUP. Introduction to the Nationwide Inpatient Sample (NIS) 2002. Rockville, MD: 2004.
    1. James AH, Bushnell CD, Jamison MG, Myers ER. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol. 2005;106(3):509–516. - PubMed
    1. James AH, Jamison MG, Biswas MS, Brancazio LR, Swamy GK, Myers ER. Acute myocardial infarction in pregnancy: a United States population-based study. Circulation. 2006;113(12):1564–1571. - PubMed

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