A case-controlled study of cognitive progression in Chinese lacunar stroke patients

Clin Neurol Neurosurg. 2008 Jul;110(7):649-56. doi: 10.1016/j.clineuro.2008.03.013. Epub 2008 May 5.


Objective: (1) To determine and compare the rates of cognitive change using global and executive psychometric measures between lacunar stroke patients and matched controls and; (2) to identify features associated with cognitive changes in patients.

Methods: Sixty-one lacunar stroke patients and 35 demographically-matched controls were followed-up for 28.6 months (range 19.4-45.9 months) with psychometric assessments performed at baseline and follow-up.

Results: Lacunar stroke patients were more impaired than controls in general and executive functions at both time points. Both groups had similar stability in all psychometric tests. Patients, but not controls, exhibited a trend for improvement in general cognitive functions overtime (interaction term, p=0.084). No patient who was non-demented at baseline became demented during the study period. Two (5.7%) and five (8.2%) incident cerebrovascular events occurred among the controls and patients, respectively. Linear regression analyses performed upon patients failed to identify any predictor for the cognitive change.

Conclusion: Similar to controls, cognition in lacunar stroke patients is stable during the first 2-3 years after the stroke. There maybe a spontaneous improvement in general cognition overtime, but this awaits confirmation by future studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Asian People
  • Brain Infarction / ethnology
  • Brain Infarction / physiopathology*
  • Brain Infarction / psychology
  • Case-Control Studies
  • China
  • Cognition / physiology*
  • Cognition Disorders / physiopathology*
  • Cognition Disorders / psychology
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests / standards
  • Neuropsychological Tests / statistics & numerical data
  • Prognosis
  • Psychometrics
  • Time Factors