Psychotropic drug tenoten activates mitogen-activated MAP/ERK kinase regulatory cascade controlling the neuroprotective effects

Bull Exp Biol Med. 2007 Sep;144(3):319-21. doi: 10.1007/s10517-007-0322-5.


For evaluation of the molecular mechanisms underlying the effects of tenoten, a preparation based on ultralow-dose antibodies to S100 proteins and intended for the therapy of anxious and depressive disorders, we studied its influence on mitogen-activated ERK kinase cascade in Helix lucorum subpharyngeal ganglion complex. Western blot analysis showed that incubation of the ganglion preparation with tenoten resulted in significant activation of mitogen-activated ERK kinases, which was reduced by PD98059 (blocker of upstream protein kinase). This attests to a specific effect of the drug on mitogen-activated ERK kinase cascade. It is hypothesized that the therapeutic efficiency of tenoten is realed to activation of mitogen-activated ERK kinase cascade.

MeSH terms

  • Animals
  • Antibodies / metabolism*
  • Antibodies / therapeutic use
  • Anxiety / drug therapy
  • Anxiety / metabolism
  • Depressive Disorder / drug therapy
  • Depressive Disorder / metabolism
  • Enzyme Activation
  • Enzyme Inhibitors / metabolism
  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Flavonoids / metabolism
  • Ganglia / metabolism
  • Helix, Snails
  • Humans
  • MAP Kinase Signaling System / physiology*
  • Mitogen-Activated Protein Kinases / metabolism*
  • Neuroprotective Agents / metabolism*
  • Psychotropic Drugs / metabolism*
  • Psychotropic Drugs / therapeutic use
  • S100 Proteins / immunology


  • Antibodies
  • Enzyme Inhibitors
  • Flavonoids
  • Neuroprotective Agents
  • Psychotropic Drugs
  • S100 Proteins
  • tenoten
  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinases
  • 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one