Structural basis of DNA quadruplex recognition by an acridine drug

J Am Chem Soc. 2008 May 28;130(21):6722-4. doi: 10.1021/ja8016973. Epub 2008 May 6.


The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecules. The structure rationalizes the existing structure-activity data and provides a starting-point for the structure-based design of quadruplex-binding ligands

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / chemistry*
  • Binding Sites
  • Crystallography, X-Ray
  • DNA / chemistry*
  • G-Quadruplexes*
  • Humans
  • Models, Molecular
  • TATA Box
  • Telomere / chemistry


  • Acridines
  • DNA
  • BRACO-19