Coating of bone-like apatite for development of bioactive materials for bone reconstruction

Biomed Mater. 2007 Dec;2(4):R17-23. doi: 10.1088/1748-6041/2/4/R01. Epub 2007 Nov 2.


Materials with bioactivity, i.e. bone-bonding ability, form a bone-like apatite layer on their surfaces in the body and bond to living bone through this bone-like apatite layer. Bone-like apatite is carbonated hydroxyapatite with small crystallites and low crystallinity. The coating of the bone-like apatite layer on the substrates is expected to be a useful technique to induce bioactivity on the substrates. The bone-like apatite layer can be formed on the surface of substrates in a solution mimicking body fluid when some functional groups are introduced to the substrates. This process is called a biomimetic process. Coating of bone-like apatite layers through this biomimetic process has received much attention in the fabrication of novel composites with bioactivity. An overview of the coating of bone-like apatite is described.

Publication types

  • Review

MeSH terms

  • Animals
  • Apatites / chemistry*
  • Bone Regeneration / physiology*
  • Bone Substitutes / chemistry*
  • Coated Materials, Biocompatible / chemistry*
  • Guided Tissue Regeneration / methods*
  • Humans
  • Tissue Engineering / methods*


  • Apatites
  • Bone Substitutes
  • Coated Materials, Biocompatible