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Review
. 2008 May;47 Suppl 2:73-88.
doi: 10.1007/s00394-008-2009-8.

The Cancer Chemopreventive Actions of Phytochemicals Derived From Glucosinolates

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Review

The Cancer Chemopreventive Actions of Phytochemicals Derived From Glucosinolates

John D Hayes et al. Eur J Nutr. .

Abstract

This article reviews the mechanisms by which glucosinolate breakdown products are thought to inhibit carcinogenesis. It describes how isothiocyanates, thiocyanates, nitriles, cyano-epithioalkanes and indoles are produced from glucosinolates through the actions of myrosinase, epithiospecifier protein and epithiospecifier modifier protein released from cruciferous vegetables during injury to the plant. The various biological activities displayed by these phytochemicals are described. In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 (NF-E2 related factor 2) and AhR (arylhydrocarbon receptor) transcription factors, and their abilities to repress NF-kappaB (nuclear factor-kappaB) activity, inhibit histone deacetylase, and inhibit cytochrome P450 are outlined. Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively. Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed.

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References

    1. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1422-35 - PubMed
    1. Cancer Res. 1999 Mar 15;59(6):1244-51 - PubMed
    1. Theor Appl Genet. 2003 Feb;106(4):727-34 - PubMed
    1. J Agric Food Chem. 2001 Dec;49(12 ):5743-9 - PubMed
    1. Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1403-9 - PubMed

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