Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms' tumor patients. A National Wilms' Tumor Study report

J J Kovalic; P R Thomas; J B Beckwith; J H Feusner; P A Norkool

doi:10.1002/1097-0142(19910115)67:2<342::aid-cncr2820670204>3.0.co;2-y

Hepatocellular carcinoma as second malignant neoplasms in successfully treated Wilms' tumor patients. A National Wilms' Tumor Study report

Cancer. 1991 Jan 15;67(2):342-4. doi: 10.1002/1097-0142(19910115)67:2<342::aid-cncr2820670204>3.0.co;2-y.

Authors

J J Kovalic¹, P R Thomas, J B Beckwith, J H Feusner, P A Norkool

Affiliation

¹ Washington University School of Medicine, St. Louis, Missouri.

PMID: 1845942
DOI: 10.1002/1097-0142(19910115)67:2<342::aid-cncr2820670204>3.0.co;2-y

Abstract

Although rare, second malignant neoplasms (SMN) after treatment for Wilms' tumor are deadly. A recent National Wilms' Tumor Study (NWTS) report identified 15 patients with second malignancies discovered over 14,381 person-years of observation. This report described four patients with secondary hepatocellular carcinoma in greater detail. These patients were strikingly similar in that all had right-sided tumors and each one had received right upper-quadrant irradiation. All patients died shortly after diagnosis of the SMN.

Publication types

Case Reports
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Carcinoma, Hepatocellular / etiology*
Female
Humans
Kidney Neoplasms / complications*
Kidney Neoplasms / therapy
Liver Neoplasms / etiology*
Male
Neoplasms, Multiple Primary*
Wilms Tumor / complications*
Wilms Tumor / therapy

Grants and funding

CA-42326/CA/NCI NIH HHS/United States