FGF21 Attenuates Lipolysis in Human Adipocytes - A Possible Link to Improved Insulin Sensitivity

FEBS Lett. 2008 May 28;582(12):1725-30. doi: 10.1016/j.febslet.2008.04.038. Epub 2008 May 5.

Abstract

Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has beneficial metabolic effects in animal models of type 2 diabetes mellitus. We assessed whether FGF21 influences lipolysis in human adipocytes and 3T3-L1 cells. FGF21 had no short-time effect (h) while a 3-day incubation with FGF21 attenuated hormone-stimulated lipolysis. FGF21 did not influence the mRNA expression of genes involved in regulating lipolysis, but significantly reduced the expression of the lipid droplet-associated phosphoprotein perilipin without affecting differentiation. Via reduced release of fatty acids into the circulation, the anti-lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / drug effects
  • Adipocytes / metabolism*
  • Animals
  • Carrier Proteins
  • Cell Differentiation / drug effects
  • Fatty Acids / blood
  • Fatty Acids / metabolism
  • Fibroblast Growth Factors / pharmacology
  • Fibroblast Growth Factors / physiology*
  • Gene Expression / drug effects
  • Glucuronidase / metabolism*
  • Humans
  • Insulin Resistance*
  • Lipolysis* / drug effects
  • Lipolysis* / genetics
  • Mice
  • Perilipin-1
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism

Substances

  • Carrier Proteins
  • Fatty Acids
  • Perilipin-1
  • Phosphoproteins
  • fibroblast growth factor 21
  • Fibroblast Growth Factors
  • Glucuronidase
  • klotho protein