Safety aspects and cholesterol-lowering efficacy of chitosan tablets

J Am Coll Nutr. 2008 Feb;27(1):22-30. doi: 10.1080/07315724.2008.10719671.


Objective: The purpose of this study was to determine the effect of two different doses of chitosan on serum fat-soluble vitamin concentrations, cholesterol concentrations, and other safety parameters.

Methods: A total of 65 men and women consumed 0, 4.5, 6.75 g per day of chitosan or 6.75 g per day glucomannan for eight weeks in a parallel, placebo-controlled, single-blind study. Altogether, 56 participants completed the study.

Results: No differences were detected among the treatments in serum vitamins (vitamin A, vitamin E, 25-hydroxyvitamin D), carotenes (alpha- and beta-carotene), clinical chemistry or hematology measurements. The changes in the total and LDL-cholesterol concentrations among the study groups were not statistically significant.

Conclusion: In the present study, the consumption of chitosan tablets was found to be safe, but there was no significant effect on cholesterol concentration.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Anticholesteremic Agents / adverse effects
  • Anticholesteremic Agents / therapeutic use*
  • Carotenoids / blood
  • Chitosan / adverse effects
  • Chitosan / therapeutic use*
  • Cholesterol / blood*
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Male
  • Middle Aged
  • Single-Blind Method
  • Treatment Outcome
  • Vitamin A / blood
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin E / blood


  • Anticholesteremic Agents
  • Vitamin A
  • Vitamin D
  • Vitamin E
  • Carotenoids
  • Chitosan
  • Cholesterol
  • 25-hydroxyvitamin D