The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs

Cell. 1991 Jan 11;64(1):63-79. doi: 10.1016/0092-8674(91)90209-h.


We have discovered a reporter gene insertion that is expressed in the trunk region of Drosophila embryos. Genetic and molecular details of a new regulatory gene neighboring the reporter gene insertion, which we call teashirt (tsh), are described. In situ hybridization of a tsh probe to embryos shows that this gene is expressed in a way similar to the reporter gene. Mutations of tsh show that the gene is required for normal development of the ventral trunk region of embryos, which correlates with the spatial expression of the gene in the anteroposterior axis but not in the dorsoventral axis. Sequencing of a tsh cDNA shows that the putative protein possesses three distantly spaced CX2CX12HX5H zinc finger motifs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Deletion
  • Chromosomes / ultrastructure
  • Cloning, Molecular
  • DNA Transposable Elements
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Embryo, Nonmammalian / physiology
  • Female
  • Genes, Regulator*
  • Genetic Vectors
  • Insect Hormones
  • Male
  • Molecular Sequence Data
  • Mutagenesis
  • Proteins / genetics
  • RNA, Antisense / genetics
  • Recombinant Fusion Proteins / metabolism
  • Repressor Proteins*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Transcription Factors*
  • Zinc Fingers / genetics*
  • beta-Galactosidase / genetics
  • beta-Galactosidase / metabolism


  • DNA Transposable Elements
  • Drosophila Proteins
  • Insect Hormones
  • Proteins
  • RNA, Antisense
  • Recombinant Fusion Proteins
  • Repressor Proteins
  • Transcription Factors
  • tsh protein, Drosophila
  • beta-Galactosidase

Associated data

  • GENBANK/M57496
  • GENBANK/M59201
  • GENBANK/M63698
  • GENBANK/M63700
  • GENBANK/M63702
  • GENBANK/M63718
  • GENBANK/S63145
  • GENBANK/S63146
  • GENBANK/S63147
  • GENBANK/S63148