Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes

Endocrinology. 1991 Jan;128(1):379-82. doi: 10.1210/endo-128-1-379.


The influence of androgen status on the regulation of lipolysis and number of beta-adrenoceptors in isolated adipocytes was studied in male rats. Castration resulted in decreased catecholamine-induced as well as forskolin-induced lipolysis. beta-adrenoceptor number, examined by a whole cell cyanopindolol binding assay, was also diminished to a similar extent. Testosterone treatment of castrated rats normalized lipolysis as well as beta-adrenoceptor number. These results demonstrate that testosterone stimulates catecholamine-induced lipolysis in vivo by increasing the number of beta-adrenoceptors as well as the activity of adenylate cyclase, confirming previous in vitro studies performed in adipose precursor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism*
  • Animals
  • Cells, Cultured
  • Iodocyanopindolol
  • Isoproterenol / pharmacology*
  • Kinetics
  • Lipolysis / drug effects*
  • Male
  • Orchiectomy
  • Pindolol / analogs & derivatives
  • Pindolol / metabolism
  • Rats
  • Rats, Inbred Strains
  • Receptors, Adrenergic, beta / drug effects
  • Receptors, Adrenergic, beta / metabolism*
  • Reference Values
  • Testosterone / pharmacology*
  • Up-Regulation


  • Receptors, Adrenergic, beta
  • Testosterone
  • Iodocyanopindolol
  • Pindolol
  • Isoproterenol