Localized 1H NMR spectroscopy in fifty cases of newly diagnosed intracranial tumors

J Comput Assist Tomogr. Jan-Feb 1991;15(1):67-76. doi: 10.1097/00004728-199101000-00009.


Fifty patients with newly diagnosed, untreated intracranial tumors were examined with 1H nuclear magnetic resonance single-volume spectroscopy (MRS) using a 1.5 T whole-body MR system. Prior to the MRS, contrast enhanced MR and/or CT imaging studies were carried out. Histological verification was obtained in all patients except one. All tumor spectra revealed distinct abnormalities as compared with the normal brain spectra. Although most meningiomas showed a rather characteristic spectral pattern, generally features specific for the various tumor types were not observed. For instance, though a strong lactic acid signal was seen in most malignant tumors, this signal was also evident in five benign neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Astrocytoma / diagnosis
  • Astrocytoma / metabolism
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / metabolism
  • Female
  • Glioma / diagnosis
  • Glioma / metabolism
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy*
  • Male
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / metabolism
  • Meningioma / diagnosis
  • Meningioma / metabolism
  • Middle Aged
  • Protons
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed


  • Protons