Manipulating midbrain stem cell self-renewal

Cell Stem Cell. 2008 May 8;2(5):405-6. doi: 10.1016/j.stem.2008.04.007.

Abstract

In this issue of Cell Stem Cell, Falk and colleagues (Falk et al., 2008) demonstrate that differential responsiveness to TGF-beta signaling selectively modulates self-renewal of dorsal midbrain stem cells. This observation may lead to strategies for expanding specific neural stem cell subtypes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Cycle Proteins / physiology
  • Cell Differentiation / physiology
  • Gene Expression Regulation, Developmental* / physiology
  • Humans
  • Mice
  • Neurons / cytology
  • Neurons / physiology*
  • Organ Specificity
  • Signal Transduction*
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Tectum Mesencephali / cytology*
  • Tectum Mesencephali / physiology
  • Transforming Growth Factor beta / physiology*
  • Wnt1 Protein / physiology

Substances

  • Cell Cycle Proteins
  • Transforming Growth Factor beta
  • Wnt1 Protein