Efficient and eco-friendly preparation of 4-methyl-5-formyl-thiazole

Nan Bai; Yaowu Sha; Ge Meng

doi:10.3390/molecules13040943

Efficient and eco-friendly preparation of 4-methyl-5-formyl-thiazole

Molecules. 2008 Apr 21;13(4):943-7. doi: 10.3390/molecules13040943.

Authors

Nan Bai¹, Yaowu Sha, Ge Meng

Affiliation

¹ The Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, PR China.

Abstract

4-Methyl-5-formylthiazole, an intermediate for synthesizing cefditoren pivoxil,was prepared in good yield by Pd/BaSO(4) catalyzed hydrogenation of 4-methylthiazole-5-carboxylic acid chloride. Detailed reaction conditions have been studied.

MeSH terms

Barium Sulfate / chemistry
Cephalosporins / chemistry
Ecology / methods
Palladium / chemistry
Particle Size
Thiazoles / chemical synthesis*
Thiazoles / chemistry
Time Factors

Substances

4-methyl-5-formyl-thiazole
Cephalosporins
Thiazoles
Barium Sulfate
Palladium
cefditoren pivoxil