Kinetic resolution of racemic pyrrolidine-2,5-diones using chiral oxazaborolidine catalysts

Mike D Barker; Rachel A Dixon; Simon Jones; Barrie J Marsh

doi:10.1039/b800510a

Kinetic resolution of racemic pyrrolidine-2,5-diones using chiral oxazaborolidine catalysts

Chem Commun (Camb). 2008 May 21:(19):2218-20. doi: 10.1039/b800510a. Epub 2008 Mar 11.

Authors

Mike D Barker¹, Rachel A Dixon, Simon Jones, Barrie J Marsh

Affiliation

¹ GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK SG1 2NY.

PMID: 18463745
DOI: 10.1039/b800510a

Abstract

Kinetic resolution of racemic C-3 substituted pyrrolidine-2,5-diones has been achieved for the first time using highly efficient oxazaborolidine catalysts derived from cis-1-amino-indan-2-ol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aza Compounds / chemistry*
Boron Compounds / chemistry*
Catalysis
Indans / chemistry
Kinetics
Stereoisomerism
Succinimides / chemistry*
Succinimides / isolation & purification

Substances

Aza Compounds
Boron Compounds
Indans
Succinimides
aminoindanol