Abstract
A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC(50) 8.18-14.08 micromol/l).
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Asteraceae / chemistry*
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Cell Line, Tumor
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Drugs, Chinese Herbal / chemistry*
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Humans
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Lactones / chemistry
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Lactones / isolation & purification*
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes, Germacrane / isolation & purification
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Lactones
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Sesquiterpenes
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Sesquiterpenes, Germacrane
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deoxyelephantopin
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elescaberin