Atrazine exposure decreases cell proliferation in Chinese Hamster Ovary (CHO-K1) cell line

Bull Environ Contam Toxicol. 2008 Aug;81(2):205-9. doi: 10.1007/s00128-008-9425-6. Epub 2008 May 9.

Abstract

The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell proliferation and IC(50) were determined with each assay after 72 h of exposure. The level of apoptosis in atrazine treated cells was low.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Atrazine / toxicity*
  • CHO Cells
  • Cell Proliferation / drug effects*
  • Coloring Agents
  • Cricetinae
  • Cricetulus
  • Herbicides / toxicity*
  • Microscopy, Fluorescence
  • Necrosis / chemically induced
  • Necrosis / pathology
  • Neutral Red
  • Organic Chemicals
  • Tetrazolium Salts
  • Thiazoles
  • Trypan Blue

Substances

  • Coloring Agents
  • Herbicides
  • Organic Chemicals
  • Tetrazolium Salts
  • Thiazoles
  • kenacid blue
  • Neutral Red
  • thiazolyl blue
  • Trypan Blue
  • Atrazine