Proliferative effects of insulin analogues on mammary epithelial cells

Arch Physiol Biochem. 2008 Feb;114(1):38-44. doi: 10.1080/13813450801900645.


Structural modification of insulin results in the generation of insulin analogues that show altered binding affinities to the insulin receptor and/or IGF-I receptor. As a consequence these insulin analogues may have increased mitogenic potency. Nine benign or malignant human mammary epithelial cells, which show different insulin receptor and IGF-I receptor expression patterns, were studied regarding mitogenicity of insulin and insulin analogues. Only insulin glargine showed a significantly higher proliferative effect on MCF-7 breast cancer cells compared to regular insulin among a panel of short- or long-acting insulin analogues, that are in clinical use.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Proliferation / drug effects
  • Epithelial Cells / cytology*
  • Epithelial Cells / drug effects
  • Epithelial Cells / pathology*
  • Humans
  • Insulin / analogs & derivatives*
  • Insulin / metabolism
  • Insulin / pharmacology*
  • Mammary Glands, Animal / cytology*
  • Mammary Glands, Animal / drug effects
  • Mammary Glands, Human / cytology*
  • Mammary Glands, Human / drug effects
  • Receptor, IGF Type 1 / metabolism


  • Insulin
  • Receptor, IGF Type 1