Exercise-induced stem cell activation and its implication for cardiovascular and skeletal muscle regeneration

Minim Invasive Ther Allied Technol. 2008;17(2):91-9. doi: 10.1080/13645700801969816.


A number of publications have provided evidence that exercise and physical activity are linked to the activation, mobilization, and differentiation of various types of stem cells. Exercise may improve organ regeneration and function. This review summarizes mechanisms by which exercise contributes to stem cell-induced regeneration in the cardiovascular and the skeletal muscle system. In addition, it discusses whether exercise may improve and support stem cell transplantation in situations of cardiovascular disease or muscular dystrophy.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / therapy
  • Cardiovascular System / metabolism
  • Exercise / physiology*
  • Humans
  • Muscle, Skeletal / metabolism
  • Muscular Dystrophies / therapy
  • Regeneration / physiology
  • Stem Cell Transplantation*
  • Stem Cells / metabolism*