Zebrafish as a New Animal Model for Movement Disorders

J Neurochem. 2008 Sep;106(5):1991-7. doi: 10.1111/j.1471-4159.2008.05463.x. Epub 2008 May 4.

Abstract

The zebrafish, long recognized as a model organism for the analysis of basic developmental processes, is now also emerging as an alternative animal model for human diseases. This review will first provide an overview of the particular characteristics of zebrafish in general and their dopaminergic nervous system in particular. We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiparkinson Agents / pharmacology*
  • Disease Models, Animal*
  • Drug Evaluation, Preclinical
  • Genetic Predisposition to Disease / genetics
  • Huntington Disease / drug therapy
  • Huntington Disease / genetics*
  • Huntington Disease / physiopathology
  • Movement Disorders / drug therapy
  • Movement Disorders / genetics*
  • Movement Disorders / physiopathology
  • Mutation / genetics
  • Parkinson Disease / drug therapy
  • Parkinson Disease / genetics*
  • Parkinson Disease / physiopathology
  • Zebrafish / genetics*
  • Zebrafish / metabolism

Substances

  • Antiparkinson Agents