The AAA+ superfamily of functionally diverse proteins

Genome Biol. 2008 Apr 30;9(4):216. doi: 10.1186/gb-2008-9-4-216.


The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Catalytic Domain
  • Nucleoside-Triphosphatase / chemistry*


  • Nucleoside-Triphosphatase