Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Jul 11;371(4):729-34.
doi: 10.1016/j.bbrc.2008.04.147. Epub 2008 May 6.

Increase of Insulin Sensitivity and Reversal of Age-Dependent Glucose Intolerance With Inhibition of ASIC3

Affiliations

Increase of Insulin Sensitivity and Reversal of Age-Dependent Glucose Intolerance With Inhibition of ASIC3

Shyh-Jer Huang et al. Biochem Biophys Res Commun. .

Abstract

Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally expressed in adipose cells. ASIC3(-/-) mice were protected against age-dependent glucose intolerance with enhanced insulin sensitivity. Acute administration of ASIC3-selective blocker APETx2 improved the glucose control and increased the insulin sensitivity in older (25-27 weeks) ASIC3(+/+) mice. Moreover, the enhanced glucose control in aging ASIC3(-/-) mice was associated with high baseline levels of Akt phosphorylation and high copy number of mitochondrial DNA in adipose tissues. Taken together, our data suggest that ASIC3 signaling might be involved in the control of age-dependent glucose intolerance and insulin resistance.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

LinkOut - more resources

Feedback