Special delivery from mitochondria to peroxisomes

Trends Cell Biol. 2008 Jun;18(6):253-6. doi: 10.1016/j.tcb.2008.04.002. Epub 2008 May 28.


Inter-organellar communication and interactions are necessary and accepted consequences of the segregation of biochemical functions into subcellular organelles. Recently, Heidi McBride and her collaborators found a novel link between mitochondria and peroxisomes in their discovery of mitochondria-derived vesicles (MDVs), which appear to fuse with a fraction of pre-existing peroxisomes in mammalian cells. We discuss the potential role of this vesicle population in the context of pathways for the exchange of metabolites and/or macromolecules between these compartments.

MeSH terms

  • Animals
  • Humans
  • Intracellular Membranes / metabolism*
  • Lipids / chemistry
  • Membrane Potentials
  • Mitochondria / metabolism*
  • Models, Biological
  • Organelles / metabolism
  • Peroxisomes / metabolism*
  • Proteomics / methods
  • Saccharomyces cerevisiae / metabolism
  • Subcellular Fractions / metabolism


  • Lipids