Poly ADP-ribose polymerase-1: an international molecule of mystery

DNA Repair (Amst). 2008 Jul 1;7(7):1077-86. doi: 10.1016/j.dnarep.2008.03.009. Epub 2008 May 12.

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the most abundant proteins within mammalian cells. First described more than 45 years ago, PARP-1 has been the subject of many studies and was shown to be involved in multiple aspects of cellular metabolism. Despite many interesting studies that implicate PARP-1 in transcription, chromatin remodelling, apoptosis, DNA repair and several neurological disorders, its precise role is still unclear. This review will discuss the role of PARP-1 in DNA repair and propose a model whereby PARP-1 operates as a modulator of base excision repair capacity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Death
  • DNA Repair*
  • Humans
  • Models, Animal
  • Models, Biological
  • Poly(ADP-ribose) Polymerases / genetics
  • Poly(ADP-ribose) Polymerases / physiology*

Substances

  • Poly(ADP-ribose) Polymerases