Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 116 (5), 680-6

A Cohort Study of Traffic-Related Air Pollution Impacts on Birth Outcomes

Affiliations

A Cohort Study of Traffic-Related Air Pollution Impacts on Birth Outcomes

Michael Brauer et al. Environ Health Perspect.

Erratum in

  • Environ Health Perspect. 2008 Dec;116(12):A519

Abstract

Background: Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts.

Objectives: We evaluated the impacts of air pollution on small for gestational age (SGA) birth weight, low full-term birth weight (LBW), and preterm birth using spatiotemporal exposure metrics.

Methods: With linked administrative data, we identified 70,249 singleton births (1999-2002) with complete covariate data (sex, ethnicity, parity, birth month and year, income, education) and maternal residential history in Vancouver, British Columbia, Canada. We estimated residential exposures by month of pregnancy using nearest and inverse-distance weighting (IDW) of study area monitors [carbon monoxide, nitrogen dioxide, nitric oxide, ozone, sulfur dioxide, and particulate matter < 2.5 (PM2.5) or < 10 (PM10) microm in aerodynamic diameter], temporally adjusted land use regression (LUR) models (NO, NO2, PM2.5, black carbon), and proximity to major roads. Using logistic regression, we estimated the risk of mean (entire pregnancy, first and last month of pregnancy, first and last 3 months) air pollution concentrations on SGA (< 10th percentile), term LBW (< 2,500 g), and preterm birth.

Results: Residence within 50 m of highways was associated with a 22% (95% CI, 0.81-1.87) [corrected] increase in LBW. Exposure to all air pollutants except O3 was associated with SGA, with similar odds ratios (ORs) for LUR and monitoring estimates (e.g., LUR: OR = 1.02; 95% CI, 1.00-1.04; IDW: OR = 1.05; 95% CI, 1.03-1.08 per 10-microg/m3 increase in NO). For preterm births, associations were observed with PM2.5 for births < 37 weeks gestation (and for other pollutants at < 30 weeks). No consistent patterns suggested exposure windows of greater relevance.

Conclusion: Associations between traffic-related air pollution and birth outcomes were observed in a population-based cohort with relatively low ambient air pollution exposure.

Keywords: air pollution; birth weight; carbon black; carbon monoxide; nitric oxide; nitrogen dioxide; particulate matter; pregnancy; pregnancy outcome; preterm birth; soot; sulfur dioxide; vehicle emissions.

Similar articles

See all similar articles

Cited by 160 PubMed Central articles

See all "Cited by" articles

References

    1. Bayer-Oglesby L, Schindler C, Hazenkamp-von Arx ME, Braun-Fahrlander C, Keidel D, Rapp R, et al. Living near main streets and respiratory symptoms in adults: the Swiss cohort study on air pollution and lung diseases in adults. Am J Epidemiol. 2006;164(12):1190–1198. - PubMed
    1. Brauer M, Gehring U, Brunekreef B, de Jongste J, Gerritsen J, Rovers M, et al. Traffic-related air pollution and otitis media. Environ Health Perspect. 2006;114:1414–1418. - PMC - PubMed
    1. Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007;29(5):879–888. - PubMed
    1. Brauer M, Hoek G, van Vliet P, Meliefste K, Fischer P, Gehring U, et al. Estimating long-term average particulate air pollution concentrations: Application of traffic indicators and geographic information systems. Epidemiology. 2003;14(2):228–239. - PubMed
    1. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med. 2002;166(8):1092–1098. - PubMed

Publication types

LinkOut - more resources

Feedback