Quantitative measurement of monoclonal antibody distribution and blood flow using positron emission tomography and 124iodine in patients with breast cancer

Int J Cancer. 1991 Feb 1;47(3):344-7. doi: 10.1002/ijc.2910470305.


The uptake and in vivo quantitation of monoclonal antibodies (MAbs) has been measured non-invasively using positron emission tomography (PET) and 124iodine in 9 patients with breast ductal carcinoma. Blood-flow measurements were also made using 15oxygen-labelled water and PET to evaluate antibody delivery; 7 patients were studied with HMFGI antibody and 2 patients with a non-specific antibody. Tumour uptake ranged from 2-7.7 x 10(-3)% of injected dose per gram of tissue. Values for normal tissues including liver, lung and bone were also obtained. In 2 out of 7 patients studied with the specific antibody, uptake was greater than that seen with the non-specific antibody. There was no correlation between antibody uptake and blood flow. This report exemplifies the potential of PET for the non-invasive and accurate quantitative assessment of targeted antibody which is a prerequisite to therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal / blood
  • Antibodies, Monoclonal / metabolism*
  • Breast Neoplasms / blood supply
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / metabolism*
  • Carcinoma, Intraductal, Noninfiltrating / blood supply
  • Carcinoma, Intraductal, Noninfiltrating / diagnostic imaging
  • Carcinoma, Intraductal, Noninfiltrating / metabolism*
  • Female
  • Humans
  • Iodine Radioisotopes
  • Middle Aged
  • Regional Blood Flow
  • Time Factors
  • Tissue Distribution
  • Tomography, Emission-Computed / methods


  • Antibodies, Monoclonal
  • Iodine Radioisotopes