The use of chemicals for facial rejuvenation has been explored since ancient times. A sound knowledge of skin anatomy and wound healing is important for understanding the principles of chemical peeling. Chemical peels are classified according to the depth of skin resurfacing produced. The main clinical indications in the cosmetic field are photoaging, dyschromias, and acne scars, which are classified according to the histologic depth of the clinical changes. Proper patient selection, skin priming, and postpeel care are of utmost importance in ensuring a satisfactory outcome. Chemical peels are combined with other rejuvenating treatments for best results in photoaging.