Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 18 (6), 291-7

HDAC6: A Key Regulator of Cytoskeleton, Cell Migration and Cell-Cell Interactions

Affiliations
Review

HDAC6: A Key Regulator of Cytoskeleton, Cell Migration and Cell-Cell Interactions

Agustín Valenzuela-Fernández et al. Trends Cell Biol.

Abstract

Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins. HDAC6 deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. Although HDAC6 enzymatic activity seems to be required for the regulation of cell morphology, the role of HDAC6 in lymphocyte chemotaxis is independent of its tubulin deacetylase activity. The diverse functions of HDAC6 suggest that it is a potential therapeutic target for the treatment of a range of diseases. This review examines the biological actions of HDAC6, focusing on its deacetylase activity and its potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role.

Similar articles

See all similar articles

Cited by 165 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback