A Glass of Water Immediately Increases Gastric pH in Healthy Subjects

Dig Dis Sci. 2008 Dec;53(12):3128-32. doi: 10.1007/s10620-008-0301-3. Epub 2008 May 13.

Abstract

Onset of action of antisecretory agents is of pivotal importance for patients with gastroesophageal reflux disease (GERD) treated "on-demand."

Aim: To study the acute effect of acid-inhibiting drugs and water administration on gastric pH.

Method: A cross-over study was performed in 12 H. pylori (-), healthy subjects (6 men; mean age: 26 years). A single oral dose of the following agents was received with a wash-out period between each study: a glass of water (200 ml), antacid, ranitidine, omeprazole, esomeprazole, and rabeprazole. Gastric pH was recorded for 6 h after drug intake.

Results: Water increased gastric pH >4 in 10/12 subjects after 1 min. The time (median) needed to pH >4 was for: antacid 2 min, ranitidine 50 min, omeprazole 171 min, esomeprazole 151 min, and rabeprazole 175 min. Gastric pH >4 lasted for 3 min after water and for 12 min after antacids; it remained >4 until the end of recording in: 4/12 subjects with ranitidine, 11/12 with rabeprazole, and all with omeprazole and esomeprazole.

Conclusion: Water and antacid immediately increased gastric pH, while PPIs showed a delayed but prolonged effect compared to ranitidine.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles / pharmacology
  • Adult
  • Antacids / pharmacology
  • Anti-Ulcer Agents / pharmacology
  • Cross-Over Studies
  • Esomeprazole
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Omeprazole / pharmacology
  • Prospective Studies
  • Proton Pump Inhibitors / pharmacology
  • Rabeprazole
  • Ranitidine / pharmacology
  • Stomach / drug effects*
  • Stomach / physiology*
  • Time Factors
  • Water / pharmacology*

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Antacids
  • Anti-Ulcer Agents
  • Proton Pump Inhibitors
  • Water
  • Rabeprazole
  • Ranitidine
  • Omeprazole
  • Esomeprazole