Biological and Pharmacological Activities of Iridoids: Recent Developments

Mini Rev Med Chem. 2008 Apr;8(4):399-420. doi: 10.2174/138955708783955926.

Abstract

Iridoids represent a large group of cyclopenta[c]pyran monoterpenoids that occur wide-spread in nature, mainly in dicotyledonous plant families like Apocynaceae, Scrophulariaceae, Diervillaceae, Lamiaceae, Loganiaceae and Rubiaceae. Recently, more extensive studies revealed that iridoids exhibit a wide range of bioactivity, such as neuroprotective, antinflammatory and immunomodulator, hepatoprotective and cardioprotective effects. Anticancer, antioxidant, antimicrobic, hypoglycaemic, hypolipidemic, choleretic, antispasmodic and purgative properties were also reported. The aim of the present review is to discuss the recent developments on biological and pharmacological activities of iridoids, supporting the new therapeutic possibilities for the use of these compounds.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / therapeutic use
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / therapeutic use
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / therapeutic use
  • Cardiotonic Agents / chemistry
  • Cardiotonic Agents / metabolism
  • Cardiotonic Agents / therapeutic use
  • Drug Design*
  • Humans
  • Immunologic Factors / chemistry
  • Immunologic Factors / metabolism
  • Immunologic Factors / therapeutic use
  • Iridoids / chemistry
  • Iridoids / metabolism*
  • Iridoids / therapeutic use*
  • Neoplasms / drug therapy*
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / metabolism
  • Neuroprotective Agents / therapeutic use

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antioxidants
  • Cardiotonic Agents
  • Immunologic Factors
  • Iridoids
  • Neuroprotective Agents