Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease

Mini Rev Med Chem. 2008 May;8(5):429-35. doi: 10.2174/138955708784223512.

Abstract

Beta-amyloid (Abeta)likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, Abeta associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of Abeta formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / antagonists & inhibitors*
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Flavonoids / chemistry
  • Flavonoids / pharmacology*
  • Humans
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / pharmacology*
  • Polyphenols

Substances

  • Amyloid beta-Peptides
  • Flavonoids
  • Phenols
  • Polyphenols