Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

Nature. 1991 Feb 21;349(6311):669-76. doi: 10.1038/349669a0.

Abstract

Traffic of MHC molecules dictates the source of peptides that are presented to T cells. The intracellular distribution of MHC class I and class II molecules reflects the dichotomy in presentation of antigen from endogenous and exogenous origin, respectively. In human B lymphoblastoid cells, class I molecules are present in compartments constituting the biosynthetic pathway, whereas class II molecules enter structures related to lysosomes during their biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD*
  • B-Lymphocytes / metabolism*
  • Biological Transport
  • Cell Line, Transformed
  • Endocytosis / immunology
  • Golgi Apparatus / metabolism
  • HLA-D Antigens / biosynthesis
  • HLA-D Antigens / metabolism*
  • Herpesvirus 4, Human
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Lysosome-Associated Membrane Glycoproteins
  • Lysosomes / chemistry
  • Lysosomes / metabolism
  • Membrane Glycoproteins / analysis
  • Membrane Proteins / analysis
  • Organelles / chemistry
  • Platelet Membrane Glycoproteins*
  • Receptor, IGF Type 2
  • Receptors, Cell Surface / analysis
  • Tetraspanin 30
  • beta-N-Acetylhexosaminidases / analysis

Substances

  • Antigens, CD
  • CD63 protein, human
  • HLA-D Antigens
  • Histocompatibility Antigens Class I
  • Lysosome-Associated Membrane Glycoproteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Platelet Membrane Glycoproteins
  • Receptor, IGF Type 2
  • Receptors, Cell Surface
  • Tetraspanin 30
  • beta-N-Acetylhexosaminidases