Membranoproliferative glomerulonephritis in patients with cystic fibrosis: coincidence or comorbidity? A case series

South Med J. 2008 Jun;101(6):641-5. doi: 10.1097/SMJ.0b013e318172f697.

Abstract

Cystic fibrosis (CF) is perceived as a childhood illness. However, with advances in medical science, patients are enjoying lives extending well into adulthood. This article reviews two cases of membranoproliferative glomerulonephritis (MPGN) in adults with CF. One patient with severe CF pulmonary disease had concomitant renal failure during hospitalization for a pulmonary exacerbation. Subsequent evaluations, including complement levels, were consistent with MPGN. The second patient had been recently diagnosed with colon cancer and was found to be suffering from acute renal failure. Diagnostic evaluation likewise confirmed the MPGN diagnosis. Immunologic associations linking CF and MPGN, including derangements in the complement system and the effects of superantigen production, are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / complications
  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / pathology
  • Adult
  • Biopsy
  • Comorbidity
  • Complement Pathway, Alternative / immunology
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / epidemiology*
  • Cystic Fibrosis / immunology
  • Female
  • Glomerulonephritis, Membranoproliferative / epidemiology*
  • Glomerulonephritis, Membranoproliferative / etiology
  • Glomerulonephritis, Membranoproliferative / immunology
  • Glomerulonephritis, Membranoproliferative / pathology
  • Humans
  • Immunity, Innate / immunology
  • Immunosuppressive Agents / therapeutic use
  • Kidney Function Tests
  • Kidney Glomerulus / pathology
  • Kidney Transplantation / immunology
  • Male
  • Neoplasm Staging
  • Renal Insufficiency / epidemiology
  • Renal Insufficiency / etiology
  • Renal Insufficiency / immunology
  • Sigmoid Neoplasms / complications
  • Sigmoid Neoplasms / diagnosis
  • Sigmoid Neoplasms / pathology
  • Superantigens / blood

Substances

  • Immunosuppressive Agents
  • Superantigens