Evolution of Brunner gland hamartoma associated with Helicobacter pylori infection

South Med J. 2008 Jun;101(6):648-50. doi: 10.1097/SMJ.0b013e318172435a.


The pathogenesis of Brunner gland hamartoma of the duodenum is unknown. This case report describes the chronology of the development of Brunner gland hamartoma from Brunner gland hyperplasia over a 12-year interval. The study subject, a 64-year-old man with chronic iron deficiency anemia, underwent serial upper endoscopies during this period. Repeated endoscopies demonstrated the evolution of Brunner gland hyperplasia, as manifest endoscopically by a submucosal mass, to a pedunculated polyp with histologic features of Brunner gland hamartoma. The duodenal polypoid mass was removed by snare polypectomy. The patient also had a chronic Helicobacter pylori infection of the stomach. This report details the time-dependent evolution of Brunner gland hyperplasia to hamartoma in association with chronic gastric H. pylori infection.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Brunner Glands / pathology*
  • Disease Progression
  • Duodenal Diseases / pathology*
  • Duodenitis / pathology*
  • Endoscopy, Digestive System
  • Follow-Up Studies
  • Hamartoma / pathology*
  • Helicobacter Infections / pathology*
  • Helicobacter pylori*
  • Humans
  • Intestinal Polyps / pathology
  • Male
  • Middle Aged