Research has suggested that women are prone to sexual regrets of action. In the present study, the authors examined "hooking up" as a predictor of sexual regret in 152 sexually active college women. Results indicate that two sexual behaviors were particularly predictive of participants' regret: (a) engaging in sexual intercourse with someone once and only once and (b) engaging in intercourse with someone known for less than 24 hr. Noncoital hookups (performing and receiving oral sex) were not significantly related to regret, indicating that college women may be underestimating the health risks associated with oral sex. Although hookups are a common feature of contemporary college life, the results counter the popular assumption that hookups are inconsequential for college women. The authors discuss the preventative health implications of their findings.