Linkage relationship between incontinentia pigmenti (IP2) and nine terminal X long arm markers

Hum Genet. 1991 Jan;86(3):297-9. doi: 10.1007/BF00202414.


Linkage data for familial incontinentia pigmenti (IP2) and nine X chromosomal markers are reported. Previously found linkage between IP2 and the DXS52 locus is confirmed with the maximum lod score of 6.19 at a recombination fraction of 0.03. Linkage is also established with loci DXS134, DXS15 and DXS33. Multipoint analysis allows us to localize the IP2 locus outside a block of seven linked markers of the Xq28 region.

Publication types

  • Case Reports

MeSH terms

  • Chromosome Mapping
  • DNA Restriction Enzymes
  • Female
  • Genes, Lethal
  • Genetic Linkage*
  • Genetic Markers
  • Humans
  • Incontinentia Pigmenti / genetics*
  • Male
  • Pedigree
  • X Chromosome*


  • Genetic Markers
  • DNA Restriction Enzymes