Beta-papillomavirus infection and skin cancer

J Invest Dermatol. 2008 Jun;128(6):1355-8. doi: 10.1038/jid.2008.123.


The development of highly sensitive PCR techniques and multiplex bead-based Luminex platforms has accelerated the search for a specific role of human papilloma viruses in the development of squamous cell carcinoma. Human papillomaviruses are most likely indirectly involved in this process by facilitating UV-related carcinogenesis via preventing UV-induced apoptosis or impairing DNA repair, but other mechanisms are also possible.

Publication types

  • Comment

MeSH terms

  • Betapapillomavirus / metabolism*
  • Carcinoma, Squamous Cell / pathology
  • Cell Transformation, Neoplastic
  • DNA Repair
  • Gene Expression Regulation, Neoplastic*
  • Gene Expression Regulation, Viral*
  • Humans
  • Neoplasms, Radiation-Induced / prevention & control
  • Neoplasms, Radiation-Induced / virology
  • Oligonucleotide Array Sequence Analysis
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / pathology
  • Skin Neoplasms / enzymology
  • Skin Neoplasms / pathology*
  • Tumor Virus Infections / complications
  • Tumor Virus Infections / virology
  • Ultraviolet Rays