Spatial and temporal coordination of mitosis by Ran GTPase

Nat Rev Mol Cell Biol. 2008 Jun;9(6):464-77. doi: 10.1038/nrm2410. Epub 2008 May 14.


The small nuclear GTPase Ran controls the directionality of macromolecular transport between the nucleus and the cytoplasm. Ran also has important roles during mitosis, when the nucleus is dramatically reorganized to allow chromosome segregation. Ran directs the assembly of the mitotic spindle, nuclear-envelope dynamics and the timing of cell-cycle transitions. The mechanisms that underlie these functions provide insights into the spatial and temporal coordination of the changes that occur in intracellular organization during the cell-division cycle.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Mitosis / genetics
  • Mitosis / physiology*
  • Mutation
  • Protein Transport / genetics
  • Protein Transport / physiology
  • ran GTP-Binding Protein / genetics
  • ran GTP-Binding Protein / metabolism
  • ran GTP-Binding Protein / physiology*


  • ran GTP-Binding Protein