Immunomodulatory and anti-SARS activities of Houttuynia cordata

J Ethnopharmacol. 2008 Jun 19;118(1):79-85. doi: 10.1016/j.jep.2008.03.018. Epub 2008 Mar 30.

Abstract

Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae)(HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia.

Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects.

Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4(+) and CD8(+) T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CL(pro)) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg.

Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Antiviral Agents / administration & dosage*
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / toxicity
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / drug effects
  • CD8-Positive T-Lymphocytes / metabolism
  • Cell Proliferation / drug effects
  • China
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / administration & dosage*
  • Drugs, Chinese Herbal / toxicity
  • Female
  • Flow Cytometry
  • Mice
  • Mice, Inbred BALB C
  • SARS Virus / drug effects*
  • Severe Acute Respiratory Syndrome / drug therapy*
  • Spleen / cytology
  • Toxicity Tests, Acute

Substances

  • Antiviral Agents
  • Drugs, Chinese Herbal
  • plant extract, Houttuynia cordata