Paraneoplastic vasculitic neuropathy: a treatable neuropathy

Muscle Nerve. 1991 Feb;14(2):152-6. doi: 10.1002/mus.880140210.


Paraneoplastic vasculitic neuropathy has been recently described. We report the first case of this disorder which responded both clinically and electrophysiologically to cyclophosphamide treatment. A 54-year-old woman with a history of metastatic endometrial carcinoma in remission had asymmetrical polyneuropathy, electrophysiological findings consistent with a diffuse axonal neuropathy, high sedimentation rate and spinal fluid protein, and microvasculitis with axonal degeneration on nerve biopsy. The patient was treated with 150 mg of cyclophosphamide daily with gradual clinical and electrophysiological improvement.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Action Potentials
  • Carcinoma / pathology
  • Carcinoma / secondary
  • Electromyography
  • Female
  • Humans
  • Leg* / blood supply
  • Leg* / innervation
  • Middle Aged
  • Neural Conduction
  • Paraneoplastic Syndromes* / physiopathology
  • Peripheral Nervous System Diseases* / physiopathology
  • Uterine Neoplasms / pathology
  • Vasculitis* / physiopathology