Histopathologic evidence of fibrovascular ingrowth four weeks after placement of the hydroxyapatite orbital implant

Am J Ophthalmol. 1991 Mar 15;111(3):363-6. doi: 10.1016/s0002-9394(14)72323-2.


We studied the histopathologic findings after placement of an orbital hydroxyapatite implant in a patient. The implant was placed after enucleation for a choroidal melanoma and was removed four weeks later because histopathologic examination of the enucleated globe disclosed tumor invasion of the optic nerve that necessitated further orbital tissue removal. Our histopathologic findings confirm that there is significant ingrowth of fibrovascular tissue in these implants, even within weeks of implantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Choroid Neoplasms / surgery
  • Connective Tissue / pathology
  • Cranial Nerve Neoplasms / pathology
  • Cranial Nerve Neoplasms / secondary
  • Durapatite
  • Eye Enucleation
  • Humans
  • Hydroxyapatites*
  • Male
  • Melanoma / secondary
  • Melanoma / surgery
  • Optic Nerve / pathology
  • Orbit / diagnostic imaging
  • Orbit / pathology
  • Orbit / surgery*
  • Prostheses and Implants*
  • Tomography, X-Ray Computed


  • Hydroxyapatites
  • Durapatite