Tissue microarray: a simple technology that has revolutionized research in pathology

J Postgrad Med. Apr-Jun 2008;54(2):158-62. doi: 10.4103/0022-3859.40790.


Tissue microarray (TMA) technology is a high-throughput research tool, which has greatly facilitated and accelerated tissue analyses by in-situ technologies. TMAs are amenable to every research method that can be applied on the standard whole sections at enhanced speed. It plays a central role in target verification of results from cDNA arrays, expression profiling of tumors and tissues, and is proving to be a powerful platform for proteomic research. In this review article, primarily meant for students of pathology and oncology, we briefly discuss its basic methodology, applications and merits and limitations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Cytological Techniques / methods*
  • Cytological Techniques / trends
  • Humans
  • Immunohistochemistry / methods
  • Immunohistochemistry / trends
  • Molecular Diagnostic Techniques
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Oligonucleotide Array Sequence Analysis / methods*
  • Prognosis
  • Quality Control
  • Tissue Array Analysis / methods*
  • Tissue Array Analysis / trends


  • Biomarkers, Tumor