Wound Repair and Regeneration

Nature. 2008 May 15;453(7193):314-21. doi: 10.1038/nature07039.

Abstract

The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fibrosis / physiopathology
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Regeneration / physiology*
  • Regenerative Medicine / trends
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Wound Healing / physiology*

Substances

  • Intercellular Signaling Peptides and Proteins