Abstract
A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-beta-D-glucopyranoside (3) and pennogenin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->3)]-beta-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Carrageenan
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Dracaena*
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Edema / chemically induced
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Edema / drug therapy
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Female
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Male
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Mannosides / chemistry
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Mannosides / isolation & purification
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Mannosides / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Rats
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Rats, Wistar
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Mannosides
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Plant Extracts
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Saponins
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pennogenin-3-O-rhamnopyranosyl-1-3-glucopyranoside
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Carrageenan